Depo-Provera is a hormonal contraceptive injection containing medroxyprogesterone acetate, a synthetic form of the hormone progesterone. It is administered every three months to prevent pregnancy. Depo-Provera works by suppressing ovulation, thickening cervical mucus to block sperm, and thinning the uterine lining to prevent implantation.
Commonly used by women seeking a long-term, reversible contraceptive method, Depo-Provera is highly effective, with a success rate of over 99% when used correctly. However, it is associated with various known side effects, such as weight gain, mood changes, decreased bone density, and menstrual irregularities. Based upon research published in March 2024, users of Depo-Provera face a 5.6 times greater chance of developing meningiomas, a form of brain tumor, than those who do not use Depo-Provera. Despite this, the makers of Depo-Provera do not warn women about this risk.